US stock indices opened lower on Tuesday, after President Donald Trump threatens pharma tariffs and amid subdued corporate earnings.

At the opening bell, the Dow Jones Industrial Average fell 218.6 points, or 0.53%, to 41,000.19. The S&P 500 fell 44.5 points, or 0.79%, to 5,605.87​, while the Nasdaq Composite dropped 221.0 points, or 1.24%, to 17,623.209.